The blast occurred early Friday with police headquarters badly destroyed.
It was followed by two smaller explosions near police stations in other areas of Cairo, one of which wounded several people.
The blasts took place at time of high tension, the day before the third anniversary of the 2011 revolution that eventually brought down the country's former authoritarian leader Hosni Mubarak.
And they come amid the instability ushered in by the military's overthrow last year of the democratically elected former president, Mohamed Morsy, and the ensuing crackdown by security forces on the Islamist movement that supported him, the Muslim Brotherhood.
Speaking close to the incident, CNN's Reza Sayah said the blast appeared to be "the most powerful bomb attack that we've seen here in central Cairo in recent memory."
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